The World No. 8, who is the top seed at the ATP 250 event, will face an Australian wild card in his opening match, with the winner of Thanasi Kokkinakis and Alexei Popyrin taking on the 12-time tour-level titlist.
The 25-year-old is seeded to meet sixth seed Miomir Kecmanovic in the quarter-finals. The Serbian begins against the returning Kyle Edmund. Rublev is also joined in the top half by fourth seed Roberto Bautista Agut, with the Spaniard opening against Frenchman Benjamin Bonzi or American Maxime Cressy.
At the bottom of the draw, second seed Pablo Carreno Busta opens against a qualifier, with fifth seed Daniel Evans a potential quarter-final opponent.
The Briton faces American Mackenzie McDonald in the first round and could meet Sebastian Korda in the second round. The 22-year-old Korda, who plays Yoshihito Nishioka in the semi-finals in Adelaide Saturday, opens against Emil Ruusuvuori.
Third seed Karen Khachanov will play Arthur Rinderknech or Marc-Andrea Huesler, while #NextGenATP Briton Jack Draper starts against Lorenzo Sonego. The Next Gen ATP Finals champion Brandon Nakashima will compete for the first time since he lifted the trophy in Milan when he plays seventh-
seeded Spaniard Alejandro Davidovich Fokina. Australian Jason Kubler earned two wins at the United Cup in Sydney. The 29-year-old will look to continue his impressive start to the season against a qualifier.